Reirradiation for progressive brain metastases
نویسندگان
چکیده
منابع مشابه
Outcomes after whole brain reirradiation in patients with brain metastases.
PURPOSE Patients with brain metastases are often treated with whole brain radiation therapy (WBRT) for purposes of palliation. The treatment of those who experience subsequent intracranial disease progression can include a second course of WBRT, although there is controversy surrounding its safety and efficacy. This study examines the outcomes in patients at Massachusetts General Hospital who u...
متن کاملThe benefit of whole brain reirradiation in patients with multiple brain metastases
BACKGROUND To assess the outcomes, symptom palliation and survival rates in patients who received repeat whole brain radiotherapy (WBRT). METHODS Twenty-eight patients who had progression of brain metastasis received a second course of WBRT. Univariate log-rank testing and multivariate Cox regression analysis were used to determine the factors for death among several variables (cumulative BED...
متن کاملEstimating prognosis at the time of repeat whole brain radiation therapy for multiple brain metastases: The reirradiation score
Purpose Whole brain radiation therapy (WBRT) remains the standard of care for patients with multiple brain metastases, but more than half of treated patients will develop intracranial progression. Because there is no clear consensus on the optimal therapeutic approach, a prognostic index would be helpful to guide treatment options at progression. We explored whether the recursive partitioning a...
متن کاملA phase II, randomized, study of weekly APG101+reirradiation versus reirradiation in progressive glioblastoma.
PURPOSE Preclinical data indicate anti-invasive activity of APG101, a CD95 ligand (CD95L)-binding fusion protein, in glioblastoma. EXPERIMENTAL DESIGN Patients (N = 91) with glioblastoma at first or second progression were randomized 1:2 between second radiotherapy (rRT; 36 Gy; five times 2 Gy per week) or rRT+APG101 (400 mg weekly i.v.). Patient characteristics [N = 84 (26 patients rRT, 58 p...
متن کاملdifferent fractionation in whole brain irradiation for multiple brain metastases
background : this study compared the efficacy of two commonly used fractionation schedules for palliative whole brain irradiation in patients with brain metastases, and assessed the association of the radiotherapy therapy oncology group (rtog) recursive partitioning analysis for brain metastases (rpa) to survival with each schedule. methods : patients with multiple (more than three) brain metas...
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ژورنال
عنوان ژورنال: Journal of Cancer Research and Therapeutics
سال: 2009
ISSN: 0973-1482
DOI: 10.4103/0973-1482.57120